FIGURE

FIGURE 3

ID

ZDB-FIG-220924-3

Publication

Wareham et al., 2022 - Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development

Other Figures

All Figure Page

Back to All Figure Page

FIGURE 3

Adamts10 MO-induced reduction in pou4f1 enhancer-driven GFP expression is decreased with normal human ADAMTS10 mRNA but not ADAMTS10^G661R mutant mRNA. Representative fluorescent images of a Tg(pou4f1-hsp70l:GFP) embryo uninjected (A) injected with adamts10 MO (B), co-injected with ADAMTS10 MO and normal human mRNA (C) and co-injected with adamts10 MO and ADAMTS10^G661R mRNA (D), showing pou4f1 enhancer-driven fluorescence in the retina (white arrows) and optic nerve (magenta arrows); scale = 250 µm. Corresponding 3D surface plots showing fluorescence intensity for each condition (E–H). Normalized integrated fluorescence density (I) of each condition (uninjected n = 7, adamts10 MO-injected n = 9, normal human mRNA-injected n = 8 and ADAMTS10^G661R mRNA n = 7, *p = 0.03, **p = 0.008,***p = 0.003, ****p < 0.0001; one-way ANOVA Tukey’s multiple comparisons test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Mol Biosci