FIGURE

Fig. 3

ID

ZDB-FIG-210218-17

Publication

Zhao et al., 2021 - Loss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish

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Fig. 3

Depletion of <italic>Δ113p53</italic> results in an elevated level of intracellular H<sub>2</sub>O<sub>2</sub> in zebrafish telencephalons.

A–C Relative mRNA expression of aldh4a1, gpx1a, sesn1, sod2 at 3- (A), 6- (B), and 10-months old (C) in the Δ113p53^+/+ or Δ113p53^M/M telencephalons. The total RNA was extracted from a pool of at least six telencephalons in each group. The average gene expression was normalized against β-actin and expressed as fold change. D The relative concentration of H₂O₂ in the Δ113p53^+/+ and Δ113p53^M/M telencephalons at 3-, 6-, and 13-months old as indicated. Each group was measured based on a pool of at least four telencephalons. Statistical analysis was performed on relevant data using the Student’s two-tailed t test. *P < 0.05, **P < 0.01, ***P < 0.001.

Expression Data

Genes:	aldh4a1 gpx1a sesn1 sod2
Fish:	sqPJR1Tg tp53^zdf1/zdf1; sqPJR1Tg
Anatomical Term:	telencephalon
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1; sqPJR1Tg
Observed In:	telencephalon
Stage:	Adult

Phenotype Detail

Acknowledgments

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