Gene
gpx1a
- ID
- ZDB-GENE-030410-1
- Name
- glutathione peroxidase 1a
- Symbol
- gpx1a Nomenclature History
- Previous Names
-
- gpx1
- cb690 (1)
- zgc:103683
- zgc:92737
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable glutathione peroxidase activity. Predicted to be involved in several processes, including glutathione metabolic process; hydrogen peroxide catabolic process; and response to selenium ion. Predicted to act upstream of or within response to oxidative stress. Predicted to be active in cytosol and mitochondrion. Is expressed in Kupffer's vesicle; digestive system; muscle; optic tectum; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); nutritional deficiency disease (multiple); and respiratory system cancer (multiple). Orthologous to human GPX1 (glutathione peroxidase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 42 figures from 33 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb690 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017876Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hemolytic anemia due to glutathione peroxidase deficiency | 614164 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glutathione peroxidase | Glutathione peroxidase active site | Thioredoxin-like superfamily |
|---|---|---|---|---|
|
UniProtKB:Q5XJ48
|
142 | |||
|
UniProtKB:A0A8M1N370
|
191 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-51M8 | ZFIN Curated Data | |
| Contains | STS | unp1670 | ||
| Encodes | EST | cb690 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:92737 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103683 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191965 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007281 (1) | 1004 nt | ||
| Genomic | GenBank:CR933559 (2) | 119833 nt | ||
| Polypeptide | UniProtKB:A0A8M1N370 (1) | 191 aa |
- Li, Q., Pei, R., Chen, E., Zheng, F., Zhang, Y., Meng, S. (2024) Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota. Heliyon. 10:e26167e26167
- Ajouaou, Y., Magnani, E., Madakashira, B., Jenkins, E., Sadler, K.C. (2023) atm Mutation and Oxidative Stress Enhance the Pre-Cancerous Effects of UHRF1 Overexpression in Zebrafish Livers. Cancers. 15(8):
- Gómez Sánchez, A., Colucci, P., Moran, A., Moya López, A., Colligris, B., Álvarez, Y., Kennedy, B.N. (2023) Systemic treatment with cigarette smoke extract affects zebrafish visual behaviour, intraocular vasculature morphology and outer segment phagocytosis. Open research Europe. 3:4848
- Li, X., Zeng, L., Qu, Z., Zhang, F. (2023) Huoxin pill protects verapamil-induced zebrafish heart failure through inhibition of oxidative stress-triggered inflammation and apoptosis. Heliyon. 10:e23402e23402
- Medkova, D., Hollerova, A., Blahova, J., Marsalek, P., Mares, J., Hodkovicova, N., Doubkova, V., Hesova, R., Tichy, F., Faldyna, M., Taştan, Y., Kotoucek, J., Svobodova, Z., Lakdawala, P. (2023) Medicine designed to combat diseases of affluence affects the early development of fish. How do plastic microparticles contribute?. The Science of the total environment. 904:166378
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Qin, M.C., Li, J.J., Zheng, Y.T., Li, Y.J., Zhang, Y.X., Ou, R.X., He, W.Y., Zhao, J.M., Liu, S.T., Liu, M.H., Lin, H.Y., Gao, L. (2023) Naringin ameliorates liver fibrosis in zebrafish by modulating IDO1-mediated lipid metabolism and inflammatory infiltration. Food & function. 14(23):10347-10361
- Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
- Xu, H., Mao, X., Nie, Z., Li, Y. (2023) Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish. Free radical biology & medicine. 203:102-113
- Xu, Y., Peng, T., Zhou, Q., Zhu, J., Liao, G., Zou, F., Meng, X. (2023) Evaluation of the oxidative toxicity induced by lead, manganese, and cadmium using genetically modified nrf2a-mutant zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 266:109550
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