FIGURE

Figure 6

ID

ZDB-FIG-200805-12

Publication

Grivas et al., 2020 - Loss of Caveolin-1 and caveolae leads to increased cardiac cell stiffness and functional decline of the adult zebrafish heart

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Figure 6

Impaired cardiac function and stiffer heart tissue in caveolae-deprived cav1^cn100 mutants. (a) Quantification of ejection fraction in cav1^+/+ and cav1^cn100 hearts. n_WT = 22, n_cn100 = 20. (b) Heart rate measurements in cav1^+/+ and cav1^cn100 animals. n_WT = 23, n_cn100 = 20. t-test, *P < 0.05. (c) AFM set-up. Cartoon made with Adobe Illustrator CC2018 (www.adobe.com). (d, e) Images of the cantilever (arrowhead), the laser beam on top of the cantilever (dashed circle, also in c) and the ventricle (asterisk). Images were taken with an inverted optical microscope (AXIO Observer D1; Carl Zeiss, Germany, see Methods). (f) Biomechanical characterization of cav1^+/+ and cav1^cn100 ventricles as measured by AFM-force spectroscopy and expressed in Young’s moduli. n_WT = 9, n_cn100 = 8, t-test, ***P < 0.001. (g) Force-distance graph for indentation and retraction of the cantilever over the ventricular surface.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cav1^cn100/cn100
Observed In:	heart heart contraction
Stage:	Adult

Phenotype Detail

Acknowledgments

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