Figure 6
- ID
- ZDB-FIG-191230-1767
- Publication
- Swire et al., 2019 - Endothelin signalling mediates experience-dependent myelination in the CNS
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(A) Timeline for the intranasal experiment. At postnatal day 21 male mice were housed on their own in isolation. Mice were given two daily administrations of saline or EDNRB agonist BQ3020 from P21-P30. Mice were analysed at P35. (B) Time spent within 2.5 cm of non-social container: Saline 57.42 s ± 24.44 n = 12, BQ3020 41.44 ± 17.43 n = 17 and social container: Saline 75.82 s ± 13.26 n = 12, BQ3020 84.96 s ± 37.20 n = 17 (mean ± standard deviation). T-test. (C) Quantification of CNP positive cells in medial prefrontal cortex layers II/III: Saline 7278 ± 1165 n = 3 mice, BQ3020 9142 ± 713.3 n = 3 mice (mean ± standard error) and layer V: Saline 17114 ± 2750 n = 5 mice, BQ3020 16154 ± 1980 n = 4 mice (mean ± standard error). (D) Mean number of myelin sheath formed by oligodendrocytes per mouse. Saline 39.54 ±0.4301 n = 4 mice, BQ3020 47.29 ± 1.687 n = 4 mice (mean ± standard error). Mann-Whitney test, p=0.0286. (E) Pooled data for number of myelin sheaths formed by layer II/III medial prefrontal cortex oligodendrocytes. Saline 39.54 ±6.973 n = 28 cells from four mice, BQ3020 47.29 ± 10.18 n = 28 cells from seven mice (mean ± standard deviation). Mann-Whitney test, p=0.0019. |