FIGURE

Figure 1—figure supplement 3.

ID

ZDB-FIG-191230-1757

Publication

Swire et al., 2019 - Endothelin signalling mediates experience-dependent myelination in the CNS

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Figure 1—figure supplement 3.

Loss of oligodendroglial EDNRB reduces myelin sheath number in the visual cortex where social isolation does not affect myelination or <italic>Edn1</italic> expression.

(A) Mean number of myelin sheath formed by oligodendrocytes per mouse. Wild type 52.57 ± 1.270 n = 4 mice, EDNRB CKO 42.39 ± 1.487 n = 4 mice, Isolated 50.32 ± 0.8755 n = 4 mice (mean ± standard error). Mann-Whitney test, p=0.0106. Kruskal-Wallis test, with Dunns post hoc. (B) Pooled data for number of myelin sheaths formed by layer II/III visual cortex oligodendrocytes. Grouped 52.57 ± 8.779 n = 28 cells from four mice, EDNRB CKO 42.39 ± 7.213 n = 28 cells from four mice, Isolated 50.32 ± 5.716 n = 28 cells from four mice (mean ± standard deviation). Kruskal-Wallis test, with Dunns post hoc. (C) Quantification of the number of Edn1 expressing Pecam1 positive cells. Grouped 0.6449 ± 0.02814 n = 4 mice, Isolated 0.63535 ± 0.02120 n = 4 mice (mean ± standard error). Mann-Whitney test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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