FIGURE

Fig. 3

ID

ZDB-FIG-181024-7

Publication

Xu et al., 2018 - Fox proteins are modular competency factors for facial cartilage and tooth specification

Other Figures

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Fig. 3

Loss of midline cartilage and pharyngeal teeth in Fox-F mutants. (A) Ventral views of dissected facial skeletons, with cartilage in blue and bones and teeth in red. Schematics show affected elements in color. Bb, basibranchials; Bh, basihyal; Ch, ceratohyal; M, Meckel's; Ptp, pterygoid process. (B) Lateral views of wild-type sibling control and foxf1; foxf2a; foxf2b triple mutant at 5 dpf. Mutants show anterior truncation of the head (arrow). (C) Dissections of neurocranial cartilages show loss of the trabecular cartilages (Tr, arrow) in foxf1; foxf2a; foxf2b triple mutants. Ep, ethmoid plate. (D) Sagittal sections through the tooth-forming seventh arch of a wild-type sibling control and foxf1; foxf2a; foxf2b triple mutant at 4 dpf. All teeth (3V1, 4V2 and 5V1) are missing in mutants. c, chorda; cb5, ceratobranchial 5; ov, otic vesicle. (E,F) Whole-mount in situ hybridizations show loss of dlx2b (E) and fgf3 (F) in the developing tooth regions (arrows) of foxf1; foxf2a; foxf2b triple mutants. Numbers denote proportions of embryos with displayed phenotypes or expression patterns. Scale bars: 25 μm.

Expression Data

Genes:	dlx2b fgf3
Fish:	WT foxf1^el658/el658; foxf2a^el616/el616; foxf2b^el621/el621
Anatomical Term:	ceratobranchial 5 primary tooth
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	foxf1^el658/el658; foxf2a^el616/el616 foxf1^el658/el658; foxf2a^el616/el616; foxf2b^el621/+ foxf1^el658/el658; foxf2a^el616/el616; foxf2b^el621/el621
Observed In:	basibranchial basihyal cartilage ceratobranchial 5 primary tooth ceratobranchial 5 tooth ceratohyal cartilage ethmoid cartilage head Meckel's cartilage neurocranial trabecula neurocranium cartilage development pharyngeal arch 1 cartilage development pharyngeal arch 2 cartilage development pterygoid process tooth 3V tooth 4V tooth 5V whole organism
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

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