PUBLICATION

Fox proteins are modular competency factors for facial cartilage and tooth specification

Authors
Xu, P., Balczerski, B., Ciozda, A., Louie, K., Oralova, V., Huysseune, A., Crump, J.G.
ID
ZDB-PUB-180520-1
Date
2018
Source
Development (Cambridge, England)   145(12): (Journal)
Registered Authors
Balczerski, Bartosz, Crump, Gage DeKoeyer, Huysseune, Ann
Keywords
Bone, Cartilage, Craniofacial, Forkhead, Foxc1, Foxf1, Foxf2, Pharyngeal arches, Sox9, Teeth, Zebrafish
MeSH Terms
  • Animals
  • Body Patterning*/genetics
  • Bone and Bones/metabolism
  • Branchial Region/metabolism
  • Cartilage/embryology*
  • Cartilage/metabolism*
  • Cell Proliferation/genetics
  • Cell Survival/genetics
  • Chondrogenesis/genetics
  • Face
  • Forkhead Transcription Factors/genetics
  • Forkhead Transcription Factors/metabolism*
  • Gene Expression Regulation, Developmental
  • Mutation/genetics
  • Neural Crest/cytology
  • Signal Transduction
  • Skull/cytology
  • Tooth/embryology*
  • Tooth/metabolism*
  • Zebrafish/embryology
  • Zebrafish Proteins/metabolism
(all 21)
PubMed
29777011 Full text @ Development
Abstract
Facial form depends on the precise positioning of cartilage, bone, and tooth fields in the embryonic pharyngeal arches. How complex signaling information is integrated to specify these cell types remains a mystery. We find that modular expression of Forkhead-domain transcription factors (Fox) in the zebrafish face arises through integration of Hh, Fgf, Bmp, Edn1, and Jagged-Notch pathways. Whereas loss of C-class Fox proteins results in reduced upper facial cartilages, loss of F-class Fox proteins results in distal jaw truncations and absent midline cartilages and teeth. We show that Fox proteins are required for Sox9a to promote chondrogenic gene expression. Fox proteins are sufficient in neural crest-derived cells for cartilage development, and neural crest-specific misexpression of Fox proteins expands the cartilage domain while inhibiting bone. These results support a modular role for Fox proteins in establishing the competency of progenitors to form cartilage and teeth in the face.
Genes / Markers
Figures
Figure Gallery (13 images) / 2
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Marker Marker Type Name
CeruleanEFGCerulean
EGFPEFGEGFP
GAL4EFGGAL4
GFPEFGGFP
KikGREFGKikGR
mCherryEFGmCherry
NTREFGNTR
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Citation
Xu, P., Balczerski, B., Ciozda, A., Louie, K., Oralova, V., Huysseune, A., Crump, J.G. (2018) Fox proteins are modular competency factors for facial cartilage and tooth specification. Development (Cambridge, England). 145(12).