FIGURE

Fig. 2

ID

ZDB-FIG-171201-29

Publication

Khatri et al., 2016 - Down-regulation of coasy, the gene associated with NBIA-VI, reduces Bmp signaling, perturbs dorso-ventral patterning and alters neuronal development in zebrafish

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Fig. 2

Morphological rescue by treatment with CoA.

Morphological comparison of ST-MO- (a,d), coasy-MO-injected embryos (b,e) and morphants treated with 100 μM CoA at 48 hpf (c,f). Embryos were injected with 1.2 (a–c) or 2.5 pmol/embryo (d–f). Embryos exposed to CoA showed a significant correction of the aberrant phenotype, in particular the antero-posterior development, brain and somites formation. All images are lateral views. The graph in panel G shows the mean CoA content (pmol/embryo) as measured by a specific LC-MS/MS method on extracts from embryos injected with ST-MO or coasy-MO, eventually treated with 100 μM CoA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-coasy
Condition:	chemical treatment by environment: coenzyme A
Knockdown Reagent:	MO1-coasy
Observed In:	brain development post-vent region somite development
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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