FIGURE

Fig. S7

ID

ZDB-FIG-171201-38

Publication

Khatri et al., 2016 - Down-regulation of coasy, the gene associated with NBIA-VI, reduces Bmp signaling, perturbs dorso-ventral patterning and alters neuronal development in zebrafish

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Fig. S7

Bmp activity at 30 hpf in the transgenic line Tg(MBmp:EGFP) and rescue by CoA injection

Representative images of Tg(Bmp:EGFP) embryos not-injected (A, B) and injected with 1.2 pmol/embryo of ST-MO (C, D) or coasy-MO (E, F) at 30 hpf. A net reduction of the fluorescence intensity is evident in coasy-morphants. Results are from one representative experiment with at least 38 embryos out of two independent replicates. CoA (0.5 pmol/embryo) was injected in the craniofacial area of Tg(Bmp:EGFP) morphants at 24 hpf (I) and Bmp activity compared to that of untreated embryos (G, H) at 60 hpf. One representative experiment out of two replicates.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

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Acknowledgments

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