FIGURE

Fig. S4

ID

ZDB-FIG-160309-19

Publication

Tang et al., 2016 - Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

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Fig. S4

Visualising neuroblastoma and ERMS metastasis in transplanted rag2^E450fs (casper) fish.

(a) Retro-orbital transplantation of a GFP-labelled neuroblastoma. White arrow indicates the site of injection; yellow arrow indicates metastasis to a region near the liver. (b) Intra-muscular transplantation of ERMS into rag2^E450fs recipient fish. White arrow indicates the site of injection; yellow arrows indicate the site of metastasis. Note that metastasis can be directly visualised by epifluorescence microscopy in the rag2^E450fs (casper) recipients (yellow arrow) but not the rag2^E450fs (AB) (open yellow arrow). H&E and anti-GFP staining on sections of the recipient animals confirmed the location of metastasis. Scale bars equal 5 mm for whole animal images, 2 mm in images of heads, 1 mm in 40x histological images; 300 µm in 100x histological images; and 100 µm in 400x histological images.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.