FIGURE

Fig. 6

ID

ZDB-FIG-151113-5

Publication

Xu et al., 2015 - Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish

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Fig. 6

The Development of VDA Region-Derived Microglia Is Independent of cMyb but Requires Runx1

(A) The VDA-region-derived coro1a-GFP⁺ cells contribute to brain microglia in 20 dpf WT and cmyb^hkz3 mutant embryos (sectioned brain).

(B) Quantification of the contribution of the VDA-region-derived brain microglia in 20-dpf WT (n = 8), cmyb^hkz3 mutant (n = 8), and 15-dpf WT larvae (n = 6). Error bars represent mean ± SEM.

(C) Microglia fail to recover in the pu.1^G242Drunx1^W84X double mutants at 6 dpf. Stacked confocal images of immunohistochemistry staining of Lcp1 of 6 dpf runx1^W84X, pu.1^G242D single mutants, and pu.1^G242Drunx1^W84X double mutant from the dorsal view of the brain.

See also Figure S3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 34, Xu, J., Zhu, L., He, S., Wu, Y., Jin, W., Yu, T., Qu, J.Y., Wen, Z., Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish, 632-641, Copyright (2015) with permission from Elsevier. Full text @ Dev. Cell