FIGURE

Fig. S3

ID

ZDB-FIG-151113-8

Publication

Xu et al., 2015 - Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish

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Fig. S3

The cmybhkz3 Mutants Exhibit a Developmental Delay and Lack T Lymphocytes and Erythrocytes.

(A) Imaging of 20 dpf WT and cmyb^hkz3 mutant. The upper larva is the WT and the lower larva is the cmyb^hkz3 mutant. The scale bar represents 2 mm.

(B) Quantification of total body length of 20 dpf WT (n=11), cmyb^hkz3 mutant (n=10) and 15 dpf WT larvae (n=11). Error bars represent mean SEM. ***, P<0.001.

(C) T cell marker rag1 is greatly reduced in 20 dpf cmyb^hkz3 mutants (lower panel) comparing with WT (upper panel). Red arrows indicate the position of thymus.

(D) Only trace amount of erythrocyte marker hemoglobin αe1 is detected in the cmyb^hkz3 mutant (lower panel) comparing with WT (upper panel) at 20 dpf. White arrows indicate erythrocytes in the tail region.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 34, Xu, J., Zhu, L., He, S., Wu, Y., Jin, W., Yu, T., Qu, J.Y., Wen, Z., Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish, 632-641, Copyright (2015) with permission from Elsevier. Full text @ Dev. Cell