ZFIN Image: Xu et al., 2015, Fig. 6

Image

Figure Caption

Fig. 6

The Development of VDA Region-Derived Microglia Is Independent of cMyb but Requires Runx1

(A) The VDA-region-derived coro1a-GFP⁺ cells contribute to brain microglia in 20 dpf WT and cmyb^hkz3 mutant embryos (sectioned brain).

(B) Quantification of the contribution of the VDA-region-derived brain microglia in 20-dpf WT (n = 8), cmyb^hkz3 mutant (n = 8), and 15-dpf WT larvae (n = 6). Error bars represent mean ± SEM.

(C) Microglia fail to recover in the pu.1^G242Drunx1^W84X double mutants at 6 dpf. Stacked confocal images of immunohistochemistry staining of Lcp1 of 6 dpf runx1^W84X, pu.1^G242D single mutants, and pu.1^G242Drunx1^W84X double mutant from the dorsal view of the brain.

See also Figure S3.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Cell, 34, Xu, J., Zhu, L., He, S., Wu, Y., Jin, W., Yu, T., Qu, J.Y., Wen, Z., Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish, 632-641, Copyright (2015) with permission from Elsevier. Full text @ Dev. Cell