FIGURE

Fig. S5

ID

ZDB-FIG-111028-24

Publication

Palencia-Desai et al., 2011 - Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function

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Fig. S5

A mixture of two different foxc1a MOs effectively inhibits endocardial differentiation but does not cause myocardial expansion. (A-H) hand2 (A,B) and cmlc2 (C,D) expression is not affected in Foxc1a morphant embryos, as analyzed by in situ hybridization at the 10-somite (A-D) and 20-somite (E-H) stages. (E,F) nfatc1 expression is absent in foxc1a MO cocktail-injected embryos. (G,H) kdrl:GFP endocardial expression is severely reduced in foxc1a MO cocktail-injected embryos. Endocardium was pseudocolored in green for illustration purpose. (A-H) Flat-mounted ventral views, anterior is upwards. (I) Percentages of foxc1a MO cocktail-injected embryos exhibiting defects in endocardial and myocardial marker expression. No embryos showed expansion in hand2 or cmlc2 expression.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO13-tp53 + MO1-foxc1a + MO3-foxc1a s843Tg + MO13-tp53 + MO1-foxc1a + MO3-foxc1a
Knockdown Reagents:	MO1-foxc1a MO3-foxc1a MO13-tp53
Observed In:	endocardium myocardium
Stage Range:	10-13 somites to Prim-15

Phenotype Detail

Acknowledgments

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