FIGURE

Fig. 7

ID

ZDB-FIG-111028-18

Publication

Palencia-Desai et al., 2011 - Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function

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Fig. 7

foxc1a function is required for the initiation of endocardial development but not for inhibition of myocardial development. (A-H) hand2 (A-D) and cmlc2 (E-H) expression is not affected in Foxc1a morphant embryos, as analyzed by in situ hybridization at the 10-somite (A-D) and 20-somite (E-H) stages. (I-L) nfatc1 expression (arrows) is reduced moderately at low foxc1a MO doses of 1.5 ng (J) and severely at higher doses of 3 ng and 4 ng (K,L) as detected by in situ hybridization. (A-L) Flat-mounted ventral views, anterior is upwards. (M) The severity and number of morphant embryos exhibiting endocardial reduction of nfatc1 increases with the dose of foxc1a morpholino, while myocardial hand2 and cmlc2 expression is not affected significantly.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-foxc1a WT + MO13-tp53 + MO3-foxc1a
Knockdown Reagents:	MO3-foxc1a MO13-tp53
Observed In:	endocardium myocardium
Stage Range:	20-25 somites to Prim-15

Phenotype Detail

Acknowledgments

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