FIGURE

Fig. 10

ID

ZDB-FIG-090804-64

Publication

Ng et al., 2009 - Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development

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Fig. 10

The ATP pathway is required for S-phase progression. (A) BrdU exposures 48-50 hpf and 72-74 hpf indicate a higher proportion of S-phase cells (y-axis) in adss morphants (^** P<0.05, ^*** P<0.005). (B) DNA content analysis plots from flow cytometry at 48 hpf and 72 hpf. (C) Graphical and tabular data for percentage of cells in G1, S or G2/M, as determined by flow cytometry. adss morphants possess elevated percentages of cells in S phase and decreased percentages in G1. (D) ccnd1 expression is expanded into the central retina of adss morphants when compared with control MO-injected embryos. ccnb1 distribution is normal.

Expression Data

Genes:	ccnb1 ccnd1
Fish:	AB AB + MO1-adssl
Knockdown Reagent:	MO1-adssl
Anatomical Terms:	ciliary marginal zone retina
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-adssl
Knockdown Reagent:	MO1-adssl
Observed In:	S phase
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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