FIGURE

Fig. 9

ID

ZDB-FIG-090804-63

Publication

Ng et al., 2009 - Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development

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Fig. 9

Requirement for adss in eye growth and gmps in pigmentation downstream of gart and paics. (A-B) Dorsal (A,A′) and lateral (B) images of control MO-injected embryos at 3 dpf. Xanthophores (yellow arrow) and iridophores (red arrow) are highlighted. (C) The adss locus and approximate position of the morpholino target site. (D-E) adss morphants are microphthalmic but have normal pigmentation. (F) The gmps locus and approximate position of the morpholino target site. (G-H) gmps morphants have nearly normal sized eyes but lack most xanthophore- and iridophore-derived pigmentation. Xanthophores can be observed (G′) but are markedly lighter than those in control-injected embryos (A′).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-adssl AB + MO1-gmps
Knockdown Reagents:	MO1-adssl MO1-gmps
Observed In:	eye iridophore pigment granule pigmentation xanthophore xanthophore pigment granule
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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