FIGURE

Fig. 3

ID

ZDB-FIG-090804-57

Publication

Ng et al., 2009 - Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development

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Fig. 3

Histological analysis of gart and paics mutants. (A-J) Transverse histological sections of wild type (A,C,E,H), gart (D,G,J) and paics (B,F,I) mutants. (A,B) paics mutants are identifiable at 48 hpf and are microphthalmic with a hypopigmented RPE. Retinal lamination and neuronal differentiation are also delayed. (C,D) gart mutants are morphologically obvious at 54 hpf and are microphthalmic with a hypopigmented RPE. Retinal lamination and neuronal differentiation are also delayed. (E-G) At 72 hpf, mutant eyes remain microphthalmic, however, the retina is well laminated and all cell types appear to be present. (H-J) At 5 dpf, mutant eyes remain microphthalmic. Scale bar: 100 μm. Dorsal is up.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gart^{hi3526bTg/hi3526bTg} paics^{hi2688Tg/hi2688Tg}
Observed In:	eye neural retina development retina layer formation retinal pigmented epithelium
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

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