FIGURE

Fig. 8

ID

ZDB-FIG-090804-62

Publication

Ng et al., 2009 - Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development

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Fig. 8

Cell proliferation and apoptosis in gart and paics mutants. (A,C) BrdU exposures 48-50 hpf and 54-56 hpf indicate that in the wild-type eye most proliferative cells are located at the retinal periphery. (B) In paics and (D) gart mutants, BrdU⁺ cells are located throughout the central retina. (E-G) BrdU exposures 96-98 hpf localized proliferative cells in the wild-type and both paics and gart mutant retinas to the retinal periphery. (H) Quantifying the percentage of BrdU⁺ cells in each retina identified significant increases in the paics and gart mutants at each time point (^** P<0.05, ^*** P<0.001). (I-L) TUNEL labeling to identify apoptotic nuclei. No increases in apoptosis over wild-type levels were observed in paics mutants at 48 hpf (I,J) or gart mutants at 54 hpf (K,L).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gart^{hi3526bTg/hi3526bTg} paics^{hi2688Tg/hi2688Tg}
Observed In:	apoptotic process cell population proliferation
Stage Range:	Long-pec to Day 4

Phenotype Detail

Acknowledgments

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