FIGURE

Fig. 3

ID

ZDB-FIG-090804-45

Publication

Drerup et al., 2009 - Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation

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Fig. 3

Disc1 morphants had a medial expansion of foxd3 and sox10 expression. (A-H) At 10s and 12s, lateral (A-D) and dorsal (E-H) views show the medial expansion and increased level of foxd3 expression in Disc1 morphants (arrows). (I-P) sox10 expression showed similar results. (Q) foxd3 in situ hybridization and Alcian Blue staining of craniofacial cartilage was done on Disc1 morphants and mismatch control-injected embryos from within the same clutch. The ratio of embryos with normal foxd3 expression was significantly reduced in embryos injected with either MOE3 or MOE8. The ratio of larvae from the same clutches with normal Alcian Blue staining (class 1) was similarly reduced. Injection of a mismatch control produced no defect in foxd3 expression or cartilage development. (R) The medial expansion of foxd3 expression can be rescued in Disc1 morphants by co-injection of 100 pg of human DISC1 mRNA (^*, P<0.01).

Expression Data

Genes:	foxd3 sox10
Fish:	WT WT + MO3-disc1 WT + MO4-disc1
Knockdown Reagents:	MO3-disc1 MO4-disc1
Anatomical Term:	cranial neural crest
Stage:	10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-disc1 WT + MO4-disc1
Knockdown Reagents:	MO3-disc1 MO4-disc1
Observed In:	cranial neural crest neural crest cell migration
Stage:	10-13 somites

Phenotype Detail

Acknowledgments

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