Gene
foxd3
- ID
- ZDB-GENE-980526-143
- Name
- forkhead box D3
- Symbol
- foxd3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including iridophore differentiation; nervous system development; and neural crest cell migration. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in vitiligo. Is expressed in several structures, including mesoderm; nervous system; neural crest; neural keel; and neural plate. Orthologous to human FOXD3 (forkhead box D3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 199 figures from 147 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
{Autoimmune disease, susceptibility to, 1} | 607836 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018122 | Fork head domain conserved site1 |
Conserved_site | IPR030456 | Fork head domain conserved site 2 |
Domain | IPR001766 | Fork head domain |
Domain | IPR047392 | Forkhead box protein D3, forkhead domain |
Family | IPR050211 | Forkhead box domain-containing protein |
Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
Protein | Length | Forkhead box domain-containing protein | Forkhead box protein D3, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:F1R5S7
|
371 |
Interactions and Pathways
No data available
Plasmids
No data available