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Phenotype Figure Summary
Marker:
cdkl5
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Varela
et al.
, 2022
Fig. 2
cdkl5
sa21938/sa21938
(AB)
, 
cdkl5
sa21938/+
(AB)
head anterior region decreased width, abnormal
head decreased length, abnormal
head posterior region decreased width, abnormal
whole organism decreased length, abnormal
Fig. 3
cdkl5
sa21938/sa21938
(AB)
head anterior region decreased width, abnormal
head decreased length, abnormal
head posterior region decreased width, abnormal
whole organism decreased length, abnormal
Fig. 4
cdkl5
sa21938/sa21938
(AB)
, 
cdkl5
sa21938/+
(AB)
ceratohyal cartilage decreased length, abnormal
ceratohyal cartilage increased angle to ceratohyal cartilage, abnormal
palatoquadrate cartilage decreased length, abnormal
ventral mandibular arch decreased length, abnormal
Fig. 5
cdkl5
sa21938/sa21938
(AB)
caudal fin principal ray bone mineralization decreased process quality, abnormal
vertebra bone mineralization decreased process quality, abnormal
Fig. 6
cdkl5
sa21938/sa21938
(AB)
, 
cdkl5
sa21938/+
(AB)
whole organism motor behavior decreased process quality, abnormal
whole organism swimming behavior decreased process quality, abnormal
Fig. 7
cdkl5
sa21938/sa21938
(AB)
, 
cdkl5
sa21938/+
(AB)
whole organism
bdnf
expression increased amount, abnormal
whole organism
drd2a
expression increased amount, abnormal
whole organism
grin1b
expression increased amount, abnormal
whole organism
grm1b
expression increased amount, abnormal
whole organism
mecp2
expression increased amount, abnormal
whole organism
mef2ca
expression increased amount, abnormal
whole organism
slc1a1
expression increased amount, abnormal
Serrano
et al.
, 2021
Fig. 1.
cdkl5
sa21938/sa21938
, 
cdkl5
sa21938/+
whole organism
cdkl5
expression decreased amount, abnormal
Fig. 2.
cdkl5
sa21938/sa21938
whole organism swimming behavior decreased process quality, abnormal
Fig. 3.
cdkl5
sa21938/sa21938
; rw0Tg
spinal accessory motor neuron neuron projection decreased branchiness, abnormal
spinal accessory motor neuron neuron projection GFP expression decreased distribution, abnormal
Fig. 5.
cdkl5
sa21938/sa21938
head decreased width, abnormal
whole organism decreased length, abnormal
Fig. 6.
cdkl5
sa21938/sa21938
; knu3Tg
brain decreased volume, abnormal
cerebellum decreased volume, abnormal
Fig. 7.
cdkl5
sa21938/sa21938
ceratohyal cartilage decreased angle to ceratohyal cartilage, abnormal
ceratohyal cartilage decreased distance ceratohyal cartilage, abnormal
Fig. S4
WT + MO1-cdkl5
, 
rw0Tg + MO1-cdkl5
spinal accessory motor neuron neuron projection decreased branchiness, abnormal
spinal accessory motor neuron neuron projection GFP expression decreased distribution, abnormal
whole organism
cdkl5
expression decreased amount, abnormal
whole organism swimming behavior decreased process quality, abnormal
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