FIGURE

Fig. 6

ID

ZDB-FIG-220607-35

Publication

Varela et al., 2022 - Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder

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Fig. 6

Behavior phenotype of mutant cdkl5 zebrafish (sa21938 line). (A) Spontaneous coiling and percentage of double coiling of wild-type (WT), heterozygous (cdkl5^+/−) and homozygous (cdkl5^−/−) embryos at 24-hpf. Data are presented as median ± interquartile range. (B) Total distance travelled by cdkl5^+/− and cdkl5^−/− mutant zebrafish embryos and WT embryos with 5 dpf, treated or not with PTZ. Data are presented as mean ± SD. (C) Percentage of time spent in the inner region of the well by 5 dpf WT, cdkl5^+/− and cdkl5^−/− embryos. Data are presented as median with interquartile range. Statistical analysis was performed using one-way ANOVA followed by Tukey’s test (B) and Kruskal–Wallis followed by Dunn multiple comparisons test (A and C). *, *** and **** indicate p < 0.05, p < 0.001 and p < 0.0001, respectively. ns indicates not significant. (D) Representative images of the locomotive trajectory of 5 dpf WT, cdkl5^+/− and cdkl5^−/− embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB cdkl5^{sa21938/sa21938} (AB) cdkl5^sa21938/+ (AB)
Condition:	chemical treatment by environment: pentetrazol
Observed In:	whole organism motor behavior whole organism swimming behavior
Stage Range:	Prim-5 to Day 5

Phenotype Detail

Acknowledgments

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