ZFIN Morpholino: MO2-etsrp

Target Location

Genome Build: GRCz11Chromosome: 16

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-etsrp

Expressed Gene	Anatomy	Figures
alas2	erythroid lineage cell	FIGURE 4 from Wu et al., 2022
cdh5	embryonic blood vessel endothelial progenitor cell (not) endothelial cell	Fig. 4 from Pociute et al., 2019 Fig. 5 from Moore et al., 2018
clec14a	cranial vasculature	Fig. 4 from Sumanas et al., 2006
dusp5	cranial vasculature	Fig. 4 from Sumanas et al., 2006
etsrp	blood vasculature lateral mesoderm	Fig. 4 , Fig. 5 from Sumanas et al., 2006

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Phenotype

Phenotype resulting from MO2-etsrp

Phenotype	Fish	Figures
angiogenic sprout mislocalised, abnormal	s843Tg + MO2-etsrp	Fig. 4 from Pociute et al., 2019
axial blood vessel blood vessel endothelial cell decreased amount, abnormal	is4Tg; s843Tg + MO2-etsrp	Fig. 3 from Chetty et al., 2020
blood cell decreased amount, abnormal	sd2Tg; tsu2013Tg + MO2-etsrp	Fig. 4 from Qiu et al., 2016
blood vasculature EGFP expression decreased distribution, abnormal	s843Tg + MO2-etsrp	Fig. 2 , Fig. 3 , Fig. 7 from Chetty et al., 2020
blood vasculature morphology, abnormal	WT + MO2-etsrp	Fig. S2 from Herpers et al., 2008

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Phenotype of all Fish created by or utilizing MO2-etsrp

Phenotype	Fish	Conditions	Figures
supraintestinal artery Kaede expression decreased amount, abnormal	ci49Tg/ci49Tg + MO1-etsrp + MO2-etsrp	light intensity	Fig. 5 from Metikala et al., 2022
supraintestinal artery decreased amount, abnormal	ci49Tg/ci49Tg + MO1-etsrp + MO2-etsrp	light intensity	Fig. 5 from Metikala et al., 2022
extension tal1 expression decreased amount, abnormal	ci49Tg/ci49Tg + MO1-etsrp + MO2-etsrp	light intensity	Fig. 5 from Metikala et al., 2022
extension inserted into supraintestinal artery, abnormal	ci49Tg/ci49Tg + MO1-etsrp + MO2-etsrp	light intensity	Fig. 5 from Metikala et al., 2022
posterior lateral mesoderm morphology, abnormal	AB + MO2-etsrp	standard conditions	Fig. 4 from Liu et al., 2008

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Citations

Include unpublished citations

Nakajima, H., Ishikawa, H., Yamamoto, T., Chiba, A., Fukui, H., Sako, K., Fukumoto, M., Mattonet, K., Kwon, H.B., Hui, S.P., Dobreva, G.D., Kikuchi, K., Helker, C.S.M., Stainier, D.Y.R., Mochizuki, N. (2023) Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Developmental Cell. 58(3):224-238.e7
Metikala, S., Warkala, M., Casie Chetty, S., Chestnut, B., Rufin Florat, D., Plender, E., Nester, O., Koenig, A.L., Astrof, S., Sumanas, S. (2022) Integration of vascular progenitors into functional blood vessels represents a distinct mechanism of vascular growth. Developmental Cell. 57(6):767-782.e6
Wu, M., Chen, Q., Li, J., Xu, Y., Lian, J., Liu, Y., Meng, P., Zhang, Y. (2022) Gfi1aa/Lsd1 Facilitates Hemangioblast Differentiation Into Primitive Erythrocytes by Targeting etv2 and sox7 in Zebrafish. Frontiers in cell and developmental biology. 9:786426
Zhao, S., Feng, S., Tian, Y., Wen, Z. (2022) Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage. Proceedings of the National Academy of Sciences of the United States of America. 119:e2119051119e2119051119
Liu, K.C., Villasenor, A., Bertuzzi, M., Schmitner, N., Radros, N., Rautio, L., Mattonet, K., Matsuoka, R.L., Reischauer, S., Stainier, D.Y., Andersson, O. (2021) Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification. eLIFE. 10:
Chestnut, B., Casie Chetty, S., Koenig, A.L., Sumanas, S. (2020) Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nature communications. 11:2796
Chetty, S.C., Sumanas, S. (2020) Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish. Developmental Biology. 465(1):11-22
Rajan, A.M., Ma, R.C., Kocha, K.M., Zhang, D.J., Huang, P. (2020) Dual function of perivascular fibroblasts in vascular stabilization in zebrafish. PLoS Genetics. 16:e1008800
Pociute, K., Schumacher, J.A., Sumanas, S. (2019) Clec14a genetically interacts with Etv2 and Vegf signaling during vasculogenesis and angiogenesis in zebrafish. BMC Developmental Biology. 19:6
Davis, J.A., Koenig, A.L., Lubert, A., Chestnut, B., Liu, F., Desai, S.P., Winkler, T., Pociute, K., Choi, K., Sumanas, S. (2018) ETS transcription factor Etsrp / Etv2 is required for lymphangiogenesis and directly regulates vegfr3 / flt4 expression. Developmental Biology. 440(1):40-52

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