Gene

gata1a

ID

ZDB-GENE-980526-268

Name

GATA binding protein 1a

Symbol

gata1a Nomenclature History

Previous Names

gata1
gta1 (1)
zg1
etID309774.11 (1)
sb:eu551
vlad tepes
vlt

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Exhibits DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including hemopoiesis; regulation of gene expression; and regulation of myeloid cell differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Down syndrome; X-linked thrombocytopenia with beta-thalassemia; beta thalassemia; and bone marrow cancer (multiple). Is expressed in several structures, including ball; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Orthologous to human GATA1 (GATA binding protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

494 figures from 346 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu551 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 26 figures from 19 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gata1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital nonspherocytic hemolytic anemia 9	Alliance	Anemia, congenital, nonspherocytic hemolytic, 9	301083
thrombocytopenia	Alliance	Thrombocytopenia, X-linked, with or without dyserythropoietic anemia	300367
transient myeloproliferative syndrome	Alliance	Leukemia, megakaryoblastic, with or without Down syndrome, somatic	159595
X-linked dyserythropoietic anemia	Alliance	Anemia, X-linked, with/without neutropenia and/or platelet abnormalities	300835
X-linked thrombocytopenia with beta-thalassemia	Alliance	Thrombocytopenia with beta-thalassemia, X-linked	314050

Associated With gata1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000679	Zinc finger, GATA-type
Family	IPR016374	Transcription factor, GATA-2/3
Family	IPR039355	Transcription factor GATA
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type