FIGURE

Fig. 7

ID

ZDB-FIG-240918-52

Publication

Albu et al., 2024 - Distinct mechanisms regulate ventricular and atrial chamber wall formation

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Fig. 7

Distinct mechanisms regulate atrial and ventricular muscle structure formation.a, b 3D airyscan images of atria from homozygous wild-type siblings and wwtr1 mutants at 124 hpf; CM membranes shown in cyan (myl7:EGFP-Hsa.HRAS). c Percentage of elongating atrial CMs in 124 hpf homozygous wild-type siblings and wwtr1 mutants (n = 11 wild types, n = 9 mutants; each data point represents one heart; two-tailed Mann-Whitney test). Error bars are mean ± SD. d–g 2D confocal planes of ventricles from 72 hpf larvae treated from 35 to 72 hpf with DMSO, K-975, IWR-1, or Rac1 inhibitor; CM membranes shown in cyan (myl7:EGFP-Hsa.HRAS) and nuclei in yellow (myl7:H2B-mScarlet). h Number of trabecular units in 72 hpf larvae treated from 35 to 72 hpf with DMSO, K-975, IWR-1, or Rac1 inhibitor (n = 5 DMSO, n = 7 K-975, n = 8 IWR-1, n = 6 Rac1 inhibitor; each data point represents one heart; ordinary one-way ANOVA with Dunnett’s multiple comparison test); red arrows point to elongating CMs; white asterisks indicate trabecular units. Error bars are mean ± SD. i Schematic summarizing the cellular and molecular processes involved in ventricular (left) and atrial (right) wall morphogenesis (manually rendered using Adobe Illustrator).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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