FIGURE

FIGURE 1

ID

ZDB-FIG-231130-31

Publication

Katkat et al., 2023 - Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cells

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FIGURE 1

Generation of the zebrafish models of melanocyte regeneration and melanoma (A) Following neocuproine (NCP) treatment, caudal fins of individual zebrafish were collected for each group (control, 1 dpa = proliferative or early regeneration stage, and 7 dpa = differentiation or late regeneration stage) and used as biological replicates (no pooling). (B) The zebrafish melanoma model was generated by outcrossing the Tg(mitfa:Hsa.HRAS^G12V,mitfa:GFP) line with the wild-type (wt) AB zebrafish. 50% of the siblings (mitfa+/−) were used as the control group. 50% of the siblings Tg (mitfa+/−,HRAS^G12V:GFP) were used to collect the nevi and melanoma tissues. Caudal fins were collected for each group and used as biological replicates (no pooling). dpa: days post-ablation.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol