FIGURE

Fig. 4

ID

ZDB-FIG-231102-57

Publication

Sun et al., 2023 - Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish

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Fig. 4

Analysis of differential gene KEGG, gene ontology (GO) enrichment after 72 hpe exposure of zebrafish to PFOA and alternatives. KEGG double Y-axis plot in (a), the bar graph shows the number of enriched differential genes and the line graph shows the Padj values. Among them, the most significant enrichment was in lipid metabolism, degradation and PPAR pathway; the changes of specific factors in PPAR pathway were plotted (b); Bubble charts (c) of Gen-X, PFOA, HFPO-TA differential gene GO analysis compared to controls. GO showed that the more significant functional enrichment was also involved in lipid metabolism related. BP: Biological Process; MF: Molecular Function.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by environment: 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid chemical treatment by environment: hexafluoropropylene oxide trimer acid chemical treatment by environment: perfluorooctanoic acid
Observed In:	fatty acid oxidation fatty acid transport lipid biosynthetic process lipid metabolic process
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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