FIGURE

Fig. 3

ID

ZDB-FIG-231102-56

Publication

Sun et al., 2023 - Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish

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Fig. 3

Differential gene analysis of zebrafish exposed to PFOA and its alternatives at 72 hpe. (a) shows the number of shared and unique differential genes between different groups. The heat map indicates the distribution of up- and down-regulated genes and cluster analysis, with up-regulation in red and down-regulation in green (b); Volcano plots indicate the number and distribution of differential genes for PFOA, Gen-X, and HFPO-TA compared with the control group, with blue genes labeled as genes with larger P values or foldchange (c1, 2, 3); Protein-Protein Interaction Networks (PPI) was drawn after 72 hpe exposure of zebrafish with PFOA and its alternatives (d). The STRING database was used to draw PPI, and the most enriched network nodes were screened by MCODE, and the size of nodes was defined by betweenness.

Expression Data

Genes:	cyp2k18 cyp2y3 fads2 fkbp1ab fkbp5 gpr143 ifit10 igfbp1a ndufb9 nlrb5 tyw1
Fish:	AB
Conditions:	chemical treatment by environment: 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid chemical treatment by environment: hexafluoropropylene oxide trimer acid chemical treatment by environment: perfluorooctanoic acid
Anatomical Term:	whole organism
Stage Range:	Protruding-mouth to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by environment: 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid chemical treatment by environment: hexafluoropropylene oxide trimer acid chemical treatment by environment: perfluorooctanoic acid
Observed In:	peroxisome proliferator activated receptor signaling pathway whole organism
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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