FIGURE

Fig. 2

ID

ZDB-FIG-231102-55

Publication

Sun et al., 2023 - Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish

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Fig. 2

Changes in lipid metabolism after 72 hpe exposure of PFOA and alternatives in zebrafish. Lipid metabolism biochemical indexes TC (a), TG (b), LDL-C (c), HDL-C (d) after exposure to PFOA and its alternatives; Representative images of neutral lipids and cholesteryl esters stained with Oil Red O (e), The box in the diagram marks the apparently positive stained section. OD 492 nm value of Oil red extracted after staining (f); Filipin staining of free cholesterol, the box in the diagram marks the apparently positive stained section (g) and image J quantification of mean fluorescence intensity (h) results were performed on exposed zebrafish. Biochemical analysis, n = 5, 40 zebrafish per group; Oil red O extraction, n = 5, 3 zebrafish per group; Filipin statistical analysis, n = 4, 4 zebrafish per group. * P < 0.05 compared with the control group. Data are expressed as mean ± SE.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by environment: 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid chemical treatment by environment: hexafluoropropylene oxide trimer acid chemical treatment by environment: perfluorooctanoic acid
Observed In:	lipid metabolic process whole organism cholesterol biosynthetic process whole organism high-density lipoprotein particle clearance whole organism low-density lipoprotein particle clearance whole organism triglyceride biosynthetic process
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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