Gene
gpr143
- ID
- ZDB-GENE-040426-1476
- Name
- G protein-coupled receptor 143
- Symbol
- gpr143 Nomenclature History
- Previous Names
-
- zgc:65915
- zgc:77322 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have L-DOPA receptor activity; amino acid binding activity; and dopamine binding activity. Involved in melanosome organization. Predicted to localize to melanosome membrane and plasma membrane. Human ortholog(s) of this gene implicated in congenital nystagmus. Is expressed in neural crest; pigment cell; retina; and retinal pigmented epithelium. Orthologous to human GPR143 (G protein-coupled receptor 143).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65915 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Burgoyne et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nystagmus 6 | Alliance | Nystagmus 6, congenital, X-linked | 300814 |
| ocular albinism 1 | Alliance | Ocular albinism, type I, Nettleship-Falls type | 300500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, family 2-like, 7TM | G-protein coupled receptor 143 |
|---|---|---|---|
|
UniProtKB:A0A8M3AWB8
|
412 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gpr143-201
(1)
|
Ensembl | 1,239 nt | ||
| mRNA |
gpr143-202
(1)
|
Ensembl | 864 nt | ||
| mRNA |
gpr143-203
(1)
|
Ensembl | 646 nt |
Interactions and Pathways
No data available
Plasmids
No data available