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Figure 3.

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ZDB-FIG-231019-10

Publication

Torraca et al., 2023 - Shigella serotypes associated with carriage in humans establish persistent infection in zebrafish

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Figure 3.

Shigella O-antigen is essential to establish persistent infection. A and B, Percentage of larvae carrying persistent infection at 144 hpi and average bacterial log₁₀CFU for wild type S. sonnei 53G and several isogenic mutants. A T3SS mutant (ΔMxiD) can establish persistent infection at similar levels as wild type. However, the –pSS mutant (depleted of the virulence plasmid) and an O-antigen mutant (ΔO-Ag) are significantly reduced in their ability to establish persistent infections. C and D, Percentage of larvae carrying persistent infection at 144 hpi and average bacterial log₁₀CFU for several S. sonnei isolates from lineage II and lineage III. Lineage II and III S. sonnei isolates are both capable of establishing persistent infections. Although belonging to different lineages, all S. sonnei isolates share an identical O-antigen. Data: mean ± SEM. Statistics: 1-way analysis of variance with Sidak correction on (A, C) percentage data or (B, D) log₁₀-transformed data. ns, P ≥ .05. **P < .01. ***P < .001. ****P < .0001. CFU, colony-forming unit; hpi, hours postinfection; ns, nonsignificant; T3SS, type III secretion system; WT, wild type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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