FIGURE

Fig. 7

ID

ZDB-FIG-230108-7

Publication

Longhitano et al., 2022 - Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma

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Fig. 7

Lactate induces changes in microglia and igfbp6b expression in a zebrafish brain tumor model A Schematic representation of the genetic components of the zebrafish GBM model; B whole mount immunofluorescence of microglia (cyano) in zic:Ras larval brains treated as indicated; C count of microglia cells in whole zic:RAS control brains and treated with 20 mM lactate, data represent the means of counts performed on 5 biological replicates for each condition; d) gene expression analysis of igfbp6a and igfbp6b in 5dpf zic:Ras control larvae and treated with 20 mM lactate. (****P < 0.0001; *P < 0.01). Scale bar in B 40 μm

Expression Data

Genes:	igfbp6a igfbp6b
Fish:	hzm5Et; io006Tg
Condition:	chemical treatment by environment: lactate
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hzm5Et; io006Tg
Condition:	chemical treatment by environment: lactate
Observed In:	brain microglial cell whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

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