FIGURE

Fig. 5

ID

ZDB-FIG-230108-5

Publication

Longhitano et al., 2022 - Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma

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Fig. 5

IGFBP6 increases sonic hedgehog signalling pathway activation in GBM and microglia.Evaluation of mRNA expression levels of SHH in microglia cells treated with IGFBP6 A, and GLI1 protein expression after IGFBP6 and cyclopamine treatment B. Evaluation of mRNA expression levels of TLR4 C and ARG1 D after IGFBP6 and cyclopamine treatment in microglia cells. Evaluation of mRNA expression levels of TLR4 after IGFBP6 and cyclopamine treatment in U-87 MG E, A-172 F and U-251 MG G cells. Effect of IGFBP6 and cyclopamine treatment on lactate production in U-87 MG H, A-172 I and U-251 MG J cells. Data are expressed as mean ± SD of at least four independent experiments. (*P < 0.05; **P < 0.005; ***P < 0.001; ****P < 0.0001)

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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