FIGURE

Fig. 1

ID

ZDB-FIG-230108-1

Publication

Longhitano et al., 2022 - Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

Lactate induces the expression of MCT1, promoting an oxidative metabolism in microglia cells. Effect of Lactate on A cell viability, B SLC16A1 (MCT1) and C SLC16A3 (MCT4) mRNA expression levels, in microglia cells. Evaluation of relative mRNA expression levels of D PGC1a, E TFAM, F ATP5F1A, G COX IV, H COX II, I CYTB, J ND4, following 24 and 48 h of lactate exposition, analyzed by Real-time PCR. The calculated value of 2^−ΔΔCt in untreated controls is 1. K Cytoplasm Mitotracker Intensity. Data are expressed as mean ± SD of at least four independent experiments. (*P < 0.05; **P < 0.005; ***P < 0.001; ****P < 0.0001). Scale bars in K 10 μm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cancer Immunol Immunother