FIGURE

FIGURE 1

ID

ZDB-FIG-221227-1

Publication

Sun et al., 2022 - Craniofacial and cardiac defects in chd7 zebrafish mutants mimic CHARGE syndrome

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FIGURE 1

Generation of chd7 zebrafish mutants. (A) Schematics of Chd7 protein and chd7 gene structure. Chd7 protein contains double CHROMO domains, an ATPase domain including a DEXDc and HELICc domain, a SLIDE/SANT domain, and double BRK domains. (B) Sequence of the chd7 ^sr5 and chd7 ^sr6 mutants. Chd7 ^sr5 contains a 55-bp deletion in the fifth exon of chd7, which generated a truncation after the first chromo domain. The deletion created a 44-amino acid frame-shift followed by a stop codon. Chd7 ^sr6 has a mutation in the twelfth exon, which encodes the DEXDc domain, and causes a deletion of two amino acids, tryptophan and threonine.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol