FIGURE
Fig. 3.
- ID
- ZDB-FIG-221226-123
- Publication
- Do et al., 2022 - Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras
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Fig. 3.
Heterobifunctional degraders efficiently disrupt BRD4 protein. (A) Molecular dynamic simulation of J252 interacting with CRBN (gold) and BRD4 (blue) proteins. The position of the luciferin-based component shows no steric collision with BRD4 or CRBN. (snapshot at 1 ns). (B) Western blot analysis of BRD4 protein after treatment with J252 and ARV-825 in human embryonic kidney (HEK) 293T cells for 24 hours with indicated concentration and β-tubulin as internal controls.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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