FIGURE

Fig. 7

ID

ZDB-FIG-221030-51

Publication

Zheng et al., 2021 - Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14

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Fig. 7

Modification crosstalk and hierarchical switch of H3-PHF14_PZP engagement. (A,B) ITC fitting curves of H3(1–13)-PHF14_PZP (A) and AF10_PZP (B) titrated with H3_(14–34) peptides with indicated modifications. N.D. = not detected. (C) A model illustrating modification switch features of H3_(1–34)-PHF14_PZP engagement. H3-Nter and H3-middle are colored magenta and orange, respectively. Indicated modifications are shown as color-coded spheres. Strictly sensitive, mildly sensitive, and tolerated modifications are denoted by red cross, half-tick, and tick signs, respectively. (D) A model highlighting hierarchical modification switch features for downregulation of the H3_(1–34)-PHF14_PZP complex formation. H3-Nter and H3-middle are colored magenta and orange, respectively. Hexagonal stars of different colors indicate protein mutations at insertion loop region, mutation at ‘α-ZP’ surface, histone modifications in H3-Nter, and histone modification in H3-middle region, respectively.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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