FIGURE

Fig. 1

ID

ZDB-FIG-221030-45

Publication

Zheng et al., 2021 - Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14

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Fig. 1

PHF14_PZP is an unmodified histone H3_(1–34) reader. (A) Schematic diagram showing the domain architecture of human PHF14. (B) PZP motif based-evolutionary analyses of PHF14 homologs using the Neighbor-Joining method. The evolutionary distances were computed using the Poisson correction method and are drawn to scale in the diagram. The numbers next to each node were given as percentages and represent bootstrap support for the node (500 replicates). Evolutionary analysis was conducted in MEGA7 (37–40). (C–E) ITC fitting curves of zebrafish PHF14_PZP (C), BRPF1_PZP (D) and AF10_PZP (E) titrated with histone H3 peptides in different frames. N.D. = not detected.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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