FIGURE

Fig. 4

ID

ZDB-FIG-221030-48

Publication

Zheng et al., 2021 - Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14

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Fig. 4

A novel recognition model for H3 peptide readout by PHF14_PZP. (A) A summary of different recognition modes of PHD fingers. PHD fingers and their ligands are depicted by cyan and yellow ribbons, respectively. Zinc ions are shown as white spheres and the corresponding secondary structure are labelled. (B) Structural alignment of H3 (yellow)-PHF14 (pale cyan), H3 (light pink)-BHC80 (blue white) and H3 (cyan)-BPTF (white) complexes in wall-eye stereo view. H3 R2, K4, and R8 are depicted as sticks. (C) Sequence alignment of different PHD finger proteins: BHC80 (2PUY), PYGO (2VP7), ING2 (2G6Q), BPTF (2F6J), UHRF1 (3SOX), TAF (5WXG), MLL4PHD6 (6O7G), AIRE (2KFT), MOZ (5B78), BRPF1 (6U04), TRIM24 (3O37), AF10 (5DAH), ORC1b (5HH7).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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