FIGURE

Fig. 4

ID

ZDB-FIG-211118-52

Publication

Hunter et al., 2021 - Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface

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Fig. 4

Single-nucleus RNA-seq demonstrates that the interface cell states are distinct from the rest of the microenvironment.

a snRNA-seq cluster assignments plotted in UMAP space. b Expression of marker genes from the scRNA-seq interface cluster in the snRNA-seq dataset. c Integrated UMAP of the snRNA-seq and scRNA-seq datasets (labeled, top plot) showing colocalization of the two interface clusters (bottom plot). d Subcluster assignments and expression of marker genes from the snRNA-seq interface cluster. e Dotplot showing expression of microenvironment cell-type specific genes within the interface subclusters. f Heatmap showing expression of the top 100 genes upregulated across all of the interface subclusters.

Expression Data

Genes:	apoa1b cenpx fabp10a fgb haus4 myhc4 mylpfa plk1 pvalb1 stmn1a
Fish:	mitfa^w2/w2; tp53^zdf1/zdf1; czt13Tg/czt13Tg
Anatomical Term:	supportive cell melanoma
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2; tp53^zdf1/zdf1; czt13Tg/czt13Tg
Observed In:	epidermis melanoma liver supportive cell muscle supportive cell
Stage:	Adult

Phenotype Detail

Acknowledgments

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