Gene
plk1
- ID
- ZDB-GENE-021115-7
- Name
- polo-like kinase 1 (Drosophila)
- Symbol
- plk1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within mitotic cell cycle and retina development in camera-type eye. Predicted to be located in midbody. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including immature eye; nervous system; neural tube; pharynx; and tail bud. Human ortholog(s) of this gene implicated in urinary bladder cancer. Orthologous to human PLK1 (polo like kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb525 (6 images)
- cb636 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi1856Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la021358Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| p09ajug | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa10264 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19428 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tju2 | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | First polo-box domain | POLO box domain | POLO box domain superfamily | Polo-like kinase 1, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Second polo-box domain | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8E6V9L0
|
||||||||||
|
UniProtKB:Q4KMI8
|
595 | |||||||||
|
UniProtKB:Q6DRK7
|
595 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-14K19 | ZFIN Curated Data | |
| Encodes | EST | cb525 | Thisse et al., 2001 | |
| Encodes | EST | cb636 | Thisse et al., 2001 | |
| Encodes | EST | fb37g11 | ||
| Encodes | EST | fb76g03 | ||
| Encodes | EST | tdsubc_2d1 | ||
| Encodes | STS | chunp30142 | ||
| Encodes | cDNA | MGC:110073 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003890 (1) | 2377 nt | ||
| Genomic | GenBank:BX004779 (1) | 196036 nt | ||
| Polypeptide | UniProtKB:Q4KMI8 (1) | 595 aa |
- Friedman, C.E., Cheetham, S.W., Negi, S., Mills, R.J., Ogawa, M., Redd, M.A., Chiu, H.S., Shen, S., Sun, Y., Mizikovsky, D., Bouveret, R., Chen, X., Voges, H.K., Paterson, S., De Angelis, J.E., Andersen, S.B., Cao, Y., Wu, Y., Jafrani, Y.M.A., Yoon, S., Faulkner, G.J., Smith, K.A., Porrello, E., Harvey, R.P., Hogan, B.M., Nguyen, Q., Zeng, J., Kikuchi, K., Hudson, J.E., Palpant, N.J. (2023) HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function. Developmental Cell. 59(1):91-107.e6
- Hunter, M.V., Moncada, R., Weiss, J.M., Yanai, I., White, R.M. (2021) Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Nature communications. 12:6278
- Missinato, M.A., Zuppo, D.A., Watkins, S.C., Bruchez, M.P., Tsang, M. (2021) Zebrafish heart regenerates after chemoptogenetic cardiomyocyte depletion. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(7):986-1000
- Rossmann, M.P., Hoi, K., Chan, V., Abraham, B.J., Yang, S., Mullahoo, J., Papanastasiou, M., Wang, Y., Elia, I., Perlin, J.R., Hagedorn, E.J., Hetzel, S., Weigert, R., Vyas, S., Nag, P.P., Sullivan, L.B., Warren, C.R., Dorjsuren, B., Greig, E.C., Adatto, I., Cowan, C.A., Schreiber, S.L., Young, R.A., Meissner, A., Haigis, M.C., Hekimi, S., Carr, S.A., Zon, L.I. (2021) Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science (New York, N.Y.). 372:716-721
- Abrams, E.W., Fuentes, R., Marlow, F.L., Kobayashi, M., Zhang, H., Lu, S., Kapp, L., Joseph, S.R., Kugath, A., Gupta, T., Lemon, V., Runke, G., Amodeo, A.A., Vastenhouw, N.L., Mullins, M.C. (2020) Molecular genetics of maternally-controlled cell divisions. PLoS Genetics. 16:e1008652
- Almawi, A.W., Langlois-Lemay, L., Boulton, S., Rodríguez González, J., Melacini, G., D'Amours, D., Guarné, A. (2020) Distinct surfaces on Cdc5/PLK Polo-box domain orchestrate combinatorial substrate recognition during cell division. Scientific Reports. 10:3379
- Hu, R., Huang, W., Liu, J., Jin, M., Wu, Y., Li, J., Wang, J., Yu, Z., Wang, H., Cao, Y. (2019) Mutagenesis of putative ciliary genes with the CRISPR/Cas9 system in zebrafish identifies genes required for retinal development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(4):5248-5256
- Winata, C.L., Łapiński, M., Pryszcz, L., Vaz, C., Bin Ismail, M.H., Nama, S., Hajan, H.S., Lee, S.G.P., Korzh, V., Sampath, P., Tanavde, V., Mathavan, S. (2017) Cytoplasmic polyadenylation-mediated translational control of maternal mRNAs directs maternal to zygotic transition. Development (Cambridge, England). 145(1)
- Fontenille, L., Rouquier, S., Lutfalla, G., Giorgi, D. (2014) Microtubule-associated protein 9 (Map9/Asap) is required for the early steps of zebrafish development. Cell cycle (Georgetown, Tex.). 13(7):1101-14
- Swartz, M.E., Wells, M.B., Griffin, M., McCarthy, N., Lovely, C.B., McGurk, P., Rozacky, J., and Eberhart, J.K. (2014) A Screen of Zebrafish Mutants Identifies Ethanol-Sensitive Genetic Loci. Alcoholism, clinical and experimental research. 38(3):694-703
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