Gene

plk1

ID

ZDB-GENE-021115-7

Name

polo-like kinase 1 (Drosophila)

Symbol

plk1 Nomenclature History

Previous Names

plk
cb525 (1)
cb636 (1)
ik:tdsubc_2d1
polo-like kinase 1
wu:fb37g11
wu:fb76g03 (1)
xx:tdsubc_2d1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Involved in mitotic cell cycle. Predicted to localize to cytoplasm; microtubule cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in urinary bladder cancer. Is expressed in several structures, including immature eye; nervous system; neural tube; pharynx; and tail bud. Orthologous to human PLK1 (polo like kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

20 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb525 (6 images)
cb636 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 18 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plk1 Human Ortholog

No data available

Associated With plk1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000959	POLO box domain
Domain	IPR033695	Second polo-box domain
Domain	IPR033701	First polo-box domain
Domain	IPR033702	Polo-like kinase 1, catalytic domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036947	POLO box domain superfamily

Domain Details Per Protein

Protein	Length	First polo-box domain	POLO box domain	POLO box domain superfamily	Polo-like kinase 1, catalytic domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Second polo-box domain	Serine/threonine-protein kinase, active site
UniProtKB:A0A8E6V9L0 InterPro
UniProtKB:Q4KMI8 InterPro PDB	595
UniProtKB:Q6DRK7 InterPro PDB	595

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	plk1-201 (1) Ensembl	Ensembl	2,538 nt	Select Tool
ncRNA	plk1-002 (1) Ensembl	Ensembl	330 nt	Select Tool
ncRNA	plk1-003 (1) Ensembl	Ensembl	338 nt	Select Tool
ncRNA	plk1-004 (1) Ensembl	Ensembl	689 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations