Gene
fgb
- ID
- ZDB-GENE-030131-9261
- Name
- fibrinogen beta chain
- Symbol
- fgb Nomenclature History
- Previous Names
-
- wu:fa55c11
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor binding activity. Acts upstream of or within blood coagulation, fibrin clot formation. Predicted to be located in extracellular region. Predicted to be part of fibrinogen complex. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in blood plasma; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in cardiovascular system disease (multiple); congenital afibrinogenemia; and end stage renal disease. Orthologous to human FGB (fibrinogen beta chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77116 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fgb | China Zebrafish Resource Center (CZRC) | |
| MO1-fgb | N/A | Vo et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital afibrinogenemia | Alliance | Afibrinogenemia, congenital | 202400 |
| congenital afibrinogenemia | Alliance | Hypofibrinogenemia, congenital | 202400 |
| Dysfibrinogenemia, congenital | 616004 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Domain | IPR012290 | Fibrinogen, alpha/beta/gamma chain, coiled coil domain |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
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Domain Details Per Protein
| Protein | Length | Fibrinogen, alpha/beta/gamma chain, coiled coil domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|
|
UniProtKB:Q6NYE1
|
485 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fabp10a:fgb-EGFP) |
|
| 1 | (9) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-75B4 | ZFIN Curated Data | |
| Encodes | EST | fa55c11 | ||
| Encodes | cDNA | MGC:77116 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212774 (1) | 1741 nt | ||
| Genomic | GenBank:BX548256 (1) | 181272 nt | ||
| Polypeptide | UniProtKB:Q6NYE1 (1) | 485 aa |
- Deng, Y., Han, X., Chen, H., Zhao, C., Chen, Y., Zhou, J., de The, H., Zhu, J., Yuan, H. (2023) Ypel5 regulates liver development and function in zebrafish. Journal of molecular cell biology. 15(3):
- Griffin, M.S., Dahlgren, A.R., Nagaswami, C., Litvinov, R.I., Keeler, K., Madenjian, C., Fuentes, R., Fish, R.J., Neerman-Arbez, M., Holinstat, M., Adili, R., Weisel, J.W., Shavit, J.A. (2023) Composition of thrombi in zebrafish: similarities and distinctions with mammals. Journal of thrombosis and haemostasis : JTH. 22(4):1056-1068
- Jin, Z., Wang, D., Lv, H., Wu, B., Li, Z., Guo, X., Wang, H., Yang, S. (2023) Loss of the adaptor protein Sh3bgrl initiates ovarian fibrosis in zebrafish. FEBS letters. 597(21):2643-2655
- Wang, N., Lan, C., Lu, H., Li, L., Liao, D., Xu, K., Sun, H., Tang, Y., Wang, Y., Mei, J., Wei, M., Wu, T., Zhu, H. (2023) Preventive effect and mechanism of Tibetan tea extract on thrombosis in arachidonic acid-induced zebrafish determined via RNA-seq transcriptome profiles. PLoS One. 18:e0285216e0285216
- Grzegorski, S.J., Zhao, Y., Richter, C.E., Ku, C.J., Lavik, K.I., Paul, D., Morrissey, J.H., Shavit, J.A. (2022) Genetic duplication of tissue factor reveals subfunctionalization in venous and arterial hemostasis. PLoS Genetics. 18:e1010534e1010534
- Zhang, Y., Ma, C., He, L., Liao, L., Guo, C., Wang, C., Gong, L., Zhou, H., Fu, K., Peng, C., Li, Y. (2022) Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish. Oxidative medicine and cellular longevity. 2022:2232365
- Zhu, H., Lan, C., Zhao, D., Wang, N., Du, D., Luo, H., Lu, H., Peng, Z., Wang, Y., Qiao, Z., Huang, Y., Sun, B. (2022) Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model. NPJ science of food. 6:5555
- Hunter, M.V., Moncada, R., Weiss, J.M., Yanai, I., White, R.M. (2021) Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Nature communications. 12:6278
- Liao, L., Zhou, M., Wang, J., Xue, X., Deng, Y., Zhao, X., Peng, C., Li, Y. (2021) Identification of the Antithrombotic Mechanism of Leonurine in Adrenalin Hydrochloride-Induced Thrombosis in Zebrafish via Regulating Oxidative Stress and Coagulation Cascade. Frontiers in pharmacology. 12:742954
- Ma, X., Chen, Y., Jiang, S., Zhao, X. (2021) A Bioassay-Based Approach for the Batch-To-Batch Consistency Evaluation of Xuesaitong Injection on a Zebrafish Thrombosis Model. Frontiers in pharmacology. 12:623533
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