FIGURE

Figure 2

ID

ZDB-FIG-211025-9

Publication

Cairns et al., 2021 - A mutant wfs1 zebrafish model of Wolfram syndrome manifesting visual dysfunction and developmental delay

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Figure 2

Effects of the unfolded protein response in wfs1a^−/− and wfs1b^−/− zebrafish. Treated zebrafish were heat shocked for 1 h at 6 hpf (groups of 50 embryos). (A) Representative images of the morphological effects for each genotype at 80 hpf. Scale bar = 1 mm. (B) Percentage of dead zebrafish at 24 hpf. Data plots represent mean ± SEM (n = 5 groups of 50). Statistical significance was determined by One-Way ANOVA with Bonferroni multiple comparisons. (C) Immunoblot of BiP in untreated and heat shocked zebrafish showing an upregulation of BiP in response to heat shock. Coomassie staining demonstrates equal loading. *p < 0.05; **p < 0.01; ****p < 0.0001; h/s: heat shock treated.

Expression Data

Antibody:	Ab13-hspa5
Fish:	AB wfs1a^{sa10021/sa10021} (AB) wfs1b^{sa16422/sa16422} (AB)
Condition:	heat shock
Anatomical Term:	whole organism
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB wfs1a^{sa10021/sa10021} (AB) wfs1b^{sa16422/sa16422} (AB)
Condition:	heat shock
Observed In:	eye pericardium post-vent region whole organism
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

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