FIGURE

Figure 5

ID

ZDB-FIG-211025-13

Publication

Cairns et al., 2021 - A mutant wfs1 zebrafish model of Wolfram syndrome manifesting visual dysfunction and developmental delay

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Figure 5

Fertility of wfs1a^−/− and wfs1b^−/− zebrafish. (A) Percentage of dead embryos at 24 hpf produced from adults < 9 months (n = 9). (B) Percentage of dead embryos at 24 hpf produced from adults > 9 months (n = 9). (C) Percentage of dead embryos at 24 hpf in randomly selected embryos from wfs1b^−/− zebrafish (male or female) that were outcrossed to WT (controls n = 9, wfs1b^−/− outcrosses n = 7). A total of 50 randomly selected embryos were placed in E3 medium, incubated overnight and any dead embryos were determined the next morning. Data plots represent mean ± SEM. Statistical significance was determined by One-Way ANOVA with Bonferroni multiple comparisons. **p < 0.01; ***p < 0.001; ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	wfs1a^{sa10021/sa10021} (AB) wfs1a^{sa10021/sa10021} (AB) wfs1b^{sa16422/sa16422} (AB) wfs1b^{sa16422/sa16422} (AB) wfs1b^sa16422/+ (AB) wfs1b^sa16422/+ (AB)
Observed In:	female organism male organism whole organism
Stage Range:	Prim-5 to Adult

Phenotype Detail

Acknowledgments

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