FIGURE

FIGURE 7

ID

ZDB-FIG-210518-56

Publication

Wiweger et al., 2021 - npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease

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FIGURE 7

Pathological changes in npc2^–/– sensory organs. (A) Cerebellum structure with Purkinje cells degeneration in npc2 mutant (gray arrow), (B) Olfactory rosette with olfactory nerves (white arrow). (C) Optic nerve ganglion. Cells with a foamy, pale cytoplasm, eosinophilic nuclei, and signs of degeneration (black arrows) within the optic tectum. (A) ML, molecular layer; P, Purkinje cell leyer; GL, granule cell layer; OfN, olfactory nerves; and OR, olfactory rosette; (B) OT, optic tectum; OpG, optic nerve ganglion. H&E staining. Scale bar = 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	npc2.1^{waw302/waw302} (TL)
Observed In:	cerebellum Purkinje cell cranial nerve I cranial nerve II hindbrain olfactory bulb optic tectum telencephalon
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.