FIGURE

FIGURE 6

ID

ZDB-FIG-210518-55

Publication

Wiweger et al., 2021 - npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease

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FIGURE 6

Pathological changes in the central nervous system in adult npc2^–/– zebrafish. (A) Luxol fast blue staining showed differences in myelination between wildtype and npc2^–/– fish. (B) Changes in habenula structure were present in some npc2^–/– fish, which lacked the characteristic structure of this part of the habenular tract. (C) Midbrain with vacuolization of the habenula tract (blue arrow) with fascicular retroflexus (blue arrowhead) and degenerative changes in the medial and lateral longitudinal fascicle. OB, olfactory bulb; OR, olfactory rosette; Te, telencephalon; TeO, tectum opticum; Ce, cerebellum; Me, medulla; PG, preglomerular complex; and PT, posterior tuberculum. (A) LFB staining. Scale bar = 500 μm. (B,C) H&E staining. Scale bar = 100 μm. (C) scale bar

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	npc2.1^{waw302/waw302} (TL)
Observed In:	cerebellum Purkinje cell fasciculus retroflexus habenula habenular commissure myelination interpeduncular nucleus tegmentum lateral longitudinal fasciculus medial longitudinal fasciculus midbrain midbrain myelination raphe nucleus
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.