FIGURE

FIGURE 3

ID

ZDB-FIG-210518-52

Publication

Wiweger et al., 2021 - npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease

Other Figures

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FIGURE 3

Specificity of Nile blue staining in the olfactory organ in npc2^–/– larvae at 5 dpf. (A–A”) untreated npc2^–/– larvae; (B–B”) treatment with 2 mM 2-hydroxypropyl-β-cyclodextrin (2HPβCD; a drug that is used in clinical trials to treat NPC patients) decreased staining intensity to wildtype levels (Figures 2A–A”); and (C–C”) treatment with 8 mM (3β)-3-(2-[diethylamino]ethoxy)androst-5-en-17-one hydrochloride (U18666A, an inhibitor of cholesterol synthesis that is used to model NPC chemically) increased staining intensity in npc2^–/– larvae. (A–C) lateral view; (A’,A”,B’,B”,C’,C”), dorsal view; and (A”,B”,C”) enlarged fragments of A’,B’,C’, respectively. Scale bar = 0.5 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL npc2.1^{waw302/waw302} (TL)
Conditions:	chemical treatment: beta-cyclodextrin chemical treatment: amphiphile
Observed In:	peripheral olfactory organ peripheral olfactory organ nile blue A
Stage:	Day 5

Phenotype Detail

Acknowledgments

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