FIGURE

FIGURE 5

ID

ZDB-FIG-210518-54

Publication

Wiweger et al., 2021 - npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease

Other Figures

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FIGURE 5

Pathological changes in soft tissues in npc2^–/– revealed by H&E staining. (A) Cells with enlarged nuclei (black arrow), hepatosteatosis with different type of fatty droplet accumulation (open arrowhead) and foam cytoplasm (asterix) were found in npc2-deficient livers. (B) Kidneys with degenerating cells (DMc) between ductal (DT) and proximal (PT) tubules. (C) Pancreas with degeneration of zymogen granules in acinar cells and cholesterol deposits. The paraffin sections are from adult npc2^–/– fish and wildtype npc2^+/+ control. Scale bar = 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	npc2.1^{waw302/waw302} (TL)
Observed In:	hepatocyte hepatocyte lipid droplet hepatocyte nucleus kidney cell pancreatic acinar cell cholesterol pancreatic acinar cell inclusion body pancreatic acinar cell zymogen granule
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.